4-(Hydroxymethyl)benzoic acid
4-Hydroxythylbenzoic acid
CAS: 3006-96-0;96937-45-0
Molecular Formula: C8H8O3
4-(Hydroxymethyl)benzoic acid - Names and Identifiers
| Name | 4-Hydroxythylbenzoic acid |
| Synonyms | HMBA hb linker HMBA LINKER HMBA Linker RARECHEM AL BO 1443 4-CARBOXYBENZYL ALCOHOL Hydroxymethylbenzoicacid 4-Hydroxythylbenzoic acid 4-HYDROXYTHYLBENZOIC ACID 4-HYDROXYMETHYLBENZOIC ACID Hydroxymethylbenzoicacid p-hydroxymethyl benzoic acid 4-(Hydroxymethyl)benzoic acid Benzoic acid, 4-(hydroxymethyl)- HMBA LINKER,4-HYDROXYTHYLBENZOIC ACID |
| CAS | 3006-96-0 96937-45-0 |
| EINECS | 628-233-9 |
| InChI | InChI=1/C8H8O3/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,9H,5H2,(H,10,11) |
| InChIKey | WWYFPDXEIFBNKE-UHFFFAOYSA-N |
4-(Hydroxymethyl)benzoic acid - Physico-chemical Properties
| Molecular Formula | C8H8O3 |
| Molar Mass | 152.15 |
| Density | 1.314±0.06 g/cm3(Predicted) |
| Melting Point | 182-185 °C (lit.) |
| Boling Point | 140-150 °C(Press: 9 Torr) |
| Flash Point | 178.1°C |
| Solubility | DMSO, Methanol |
| Vapor Presure | 2.03E-05mmHg at 25°C |
| Appearance | Coarse Fibers |
| Color | White |
| BRN | 2690023 |
| pKa | 4.16±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6 |
| MDL | MFCD00017598 |
| Use | Solid phase polypeptide synthesis ligating reagent. |
4-(Hydroxymethyl)benzoic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29181990 |
4-(Hydroxymethyl)benzoic acid - Introduction
4-hydroxyethylbenzoic acid (4-hydroxyethylbenzoic acid) is an organic compound with the molecular formula C9H10O3 and a molecular weight of 166.17. The following is a description of its nature, use, preparation and safety information:
Properties: 4-hydroxyylbenzoic acid is a white or slightly yellow crystalline solid. It is soluble in alcohol, ether, chloroform and acetic acid at room temperature. This compound can form a dimeric structure through intramolecular hydrogen bonding.
use: 4-hydroxyylbenzoic acid has a variety of applications in the chemical industry. It is frequently used as an intermediate in the preparation of other organic compounds, for example in the preparation of pharmaceuticals and commodity chemicals. In addition, it can also be used as a component of photochemical materials, such as for the preparation of polyesters and polyethers with photosensitivity.
Preparation method: 4-hydroxyethylbenzoic acid can be obtained by reacting 4-hydroxymethylanisole (4-Hydroxybenzyl methyl ether) with Chloroacetic acid (Chloroacetic acid). The reaction is usually carried out under basic conditions, and the desired product is obtained by purification by distillation.
Safety information: Safety information about 4-hydroxyylbenzoic acid has not been fully reported. However, according to relevant experiments and conjectures, the substance may be irritating to the eyes and skin. Appropriate personal protective measures, such as wearing eye and skin protection equipment, should be taken when using and handling the compound. In addition, avoid inhaling its dust or solution, and avoid reacting with other chemicals. It is important to note that any chemical should be used under the guidance of a safety label and properly stored and handled in accordance with local regulations. If necessary, professional guidance should be sought.
Properties: 4-hydroxyylbenzoic acid is a white or slightly yellow crystalline solid. It is soluble in alcohol, ether, chloroform and acetic acid at room temperature. This compound can form a dimeric structure through intramolecular hydrogen bonding.
use: 4-hydroxyylbenzoic acid has a variety of applications in the chemical industry. It is frequently used as an intermediate in the preparation of other organic compounds, for example in the preparation of pharmaceuticals and commodity chemicals. In addition, it can also be used as a component of photochemical materials, such as for the preparation of polyesters and polyethers with photosensitivity.
Preparation method: 4-hydroxyethylbenzoic acid can be obtained by reacting 4-hydroxymethylanisole (4-Hydroxybenzyl methyl ether) with Chloroacetic acid (Chloroacetic acid). The reaction is usually carried out under basic conditions, and the desired product is obtained by purification by distillation.
Safety information: Safety information about 4-hydroxyylbenzoic acid has not been fully reported. However, according to relevant experiments and conjectures, the substance may be irritating to the eyes and skin. Appropriate personal protective measures, such as wearing eye and skin protection equipment, should be taken when using and handling the compound. In addition, avoid inhaling its dust or solution, and avoid reacting with other chemicals. It is important to note that any chemical should be used under the guidance of a safety label and properly stored and handled in accordance with local regulations. If necessary, professional guidance should be sought.
Last Update：2024-04-09 20:52:54
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